Design of Novel JNK3 Inhibitors Based on 3D-QSAR In Silico Model
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چکیده
منابع مشابه
Structure Based 3D-QSAR Studies on Cholinesterase Inhibitors
Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disorder of the elderly. It is characterized by widespread loss of central cholinergic neuronal function (Butters et al., 1995). The only symptomatic treatment proven to be effective to date is the use of cholinesterase inhibitors (ChEI) to augment surviving cholinergic activity (Giacobini, 2003, Terry & Buccafusco, 2003). Two t...
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The enzyme β-1,3-glucan synthase, which catalyzes the synthesis of β-1,3-glucan, an essential and unique structural component of the fungal cell wall, has been considered as a promising target for the development of less toxic anti-fungal agents. In this study, a robust pharmacophore model was developed and structure activity relationship analysis of 42 pyridazinone derivatives as β-1,3-glucan ...
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ژورنال
عنوان ژورنال: Journal of the Chosun Natural Science
سال: 2012
ISSN: 2005-1042
DOI: 10.13160/ricns.2012.5.1.006